1. Calculate the excitation light fluence rate due to every excitation source i,
using Eq. (12)
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2. Calculate the Green function at the emission wavelength,
using Eq. (13)
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3. Choose the rows corresponding to the detector points associated with every source i,
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4. Normalize the emission light fluence rate at detectors corresponding to excitation source i and get the corresponding Green’s function,
and
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5. Initialize the permissible region R: points corresponding to the whole object domain except points of one transport length
from the object boundary.
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6. Initialize permissible region reduction factor
, where
is the initial number of points in the permissible region R,
is the final number of points which can be chosen to be one, and
is the number of iterations. |
7. Solve the iterative minimization problem: |
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7.1. for j = 1:
solve the minimization problem in Eq. (15) and store the result
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7.2. Sort the fluorophore concentration values and choose number of points equals
corresponding to the highest concentration values. |
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7.3. Update the permissible region R to be the new chosen points. |
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7.4. If the value of f(j) is smaller than the previous iteration, then update the best fluorophore concentration estimation to be C:
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7.5. End the for loop |
8. End |