Table 2.

Genotype frequencies, comparison of disease-free survival by genotype, and Cox proportional hazards analysis for the age-associated risk of CRC by genotype.

	HWE Exact P	n (%)	CRC events	Log-rank test P	Univariate HR (95% CI)	P	Adjusted*HR (95% CI)	P
		Total n = 257	120
CYP1A1 I462V
AA	0.15	222 (86.4)	99	0.018	Ref	-	Ref	-
AG		32 (12.4)	21		1.81 (1.19-2.75)	0.005	1.78 (1.16 - 2.74)	0.008
GG†		3 (1.2)	0		-	-	-	-
Any G (AG+GG)		35 (13.6)	21	0.036	1.63 (1.08 2.44)	0.02	1.62(1.06-2.45)	0.02
CYP1A1 Msp1
TT	0.62	187 (72.8)	83	0.06	Ref	-	Ref	-
TC		66 (25.7)	37		1.41 (1.01-1.97)	0.04	1.53(1.06 - 2.22)	0.02
CC†		4 (1.5)	0		-	-	-	-
Any C(TC+CC)		70 (27.2)	37	0.17	1.31 (0.93-1.84)	0.13	1.44 (0.99 - 2.09)	0.06
EPHX1 Y113H
TT	0.65	130 (50.6)	66	0.46	Ref	-	Ref	-
TC		108 (42.0)	46		0.9 (0.63-1.27)	0.55	0.88 (0.62-1.26)	0.49
CC		19 (7.4)	8		0.64 (0.27-1.51)	0.31	0.62 (0.25-1.51)	0.29
Any C (TC+CC)		127 (49.4)	54	0.37	0.85 (0.61-1.19)	0.34	0.83 (0.59-1.17)	0.29
EPHX1 H139R
AA	0.58	155 (60.3)	77	0.34	Ref	-	Ref	-
AG		92 (35.8)	37		0.77 (0.55-1.08)	0.13	0.74 (0.52-1.04)	0.09
GG		10 (3.9)	6		1.18 (0.40-3.49)	0.76	1.17 (0.4-3.4)	0.77
Any G (AG+GG)		102 (39.7)	43	0.26	0.81 (0.58-1.14)	0.22	0.78 (0.55-1.1)	0.16
GSTP1 I105V
AA	1	120 (46.7)	55	0.75	Ref	-	Ref	-
AG		112 (43.6)	54		1.13 (0.81-1.57)	0.48	1.11 (0.79-1.54)	0.54
GG		25 (9.7)	11		0.93 (0.48-1.79)	0.83	0.85 (0.44-1.65)	0.64
Any G (AG+GG)		137 (53.3)	65	0.64	1.09 (0.79-1.5)	0.78	1.06 (0.76-1.46)	0.73
GSTP1 A114V
CC	1	227 (88.3)	105	0.49	Ref	-	Ref	-
CT		30 (11.7)	15		0.83 (0.5-1.34)	0.44	0.75 (0.44-1.28)	0.3
GSTM1
+ (Gene present)	-	144 (56.0)	68	0.81	Ref	-	Ref	-
− (Null)		113 (44.0)	52		0.96 (0.66-1.38)	0.81	0.98 (0.67-1.43)	0.92
GSTT1
+ (Gene present)	-	198 (77.0)	95	0.79	Ref	-	Ref	-
− (Null)		59 (23.0)	25		1.06 (0.75-1.49)	0.73	1.05 (0.74-1.49)	0.78

^*Adjusted for gender, ethnicity (white or non-white), and gene mutated (MLH1 or MSH2 ).

^†Hazard ratios omitted as estimates are unreliable with small numbers. HWE = Hardy-Weinberg equilibrium.