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Mitochondrial dysfunction induced by UQCRC2 downregulation enhances RWE-induced mucin production in the airways. Down-regulation of UQCRC2, but not UQCRC1, increases the levels of MUC5AC in the bronchoalveolar lavage fluids (A) and increases the metaplasia of mucuos cells in airway epithelium (B) of RWE-challenged mice. Inset: endpoint titers of MUC5AC in the samples. **P< 0.01 vs. mock-treated, RWE-challenged mice.
