FIG. 6.
Effect of Ine, Pe1, and SI mutations on reporter activities in transfected cells. (A) Schematic of single or double mutations introduced into the short promoters of reporters FO15Luc, AC8Luc, and 8×ECol2a1-FO15Luc driven by the short or long Matn1 promoter or multiple copies of ECol2a1 fused to the short promoter, respectively, as seen on their full maps (bottom). (B to D) Luciferase activities of wild-type (wt) and mutant reporters in the low-, high-, and nonexpressing HDM, CEC, and CEF cultures, respectively, are presented as fold values relative to that for FO15Luc. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (compared with wild-type reporter). nd, not determined.