TABLE 3.
Strain or mutation | Dapsone MIC (μg/ml) | Reference of footpad test |
---|---|---|
Wild type | 0.5 | |
48-1 (Val → Ile) | 0.5 | |
48-2 (Val → Leu) | 0.5 | |
48-3 (Val → Phe) | 1.0 | |
48-4 (Val → Asp) | —a | |
48-5 (Val → Ala) | 1.0 | |
48-6 (Va → Gly) | 1.0 | |
53-1 (Thr → Ala) | 4.0 | 6 |
53-2 (Thr → Ile) | 8.0 | 6, 10, 16 |
53-3 (Thr → Ser) | 0.25 | |
53-4 (Thr → Pro) | 2.0 | |
53-5 (Thr → Asn) | 2.0 | |
53-6 (Thr → Ser) | 0.25 | |
54-1 (Arg → Arg) | 0.5 | |
54-2 (Arg → Gly) | 1.0 | |
54-3 (Arg → Trp) | 0.5 | |
55-1 (Pro → Thr) | 1.0 | |
55-2 (Pro → Ala) | 2.0 | |
55-3 (Pro → Ser) | 2.0 | |
55-4 (Pro → His) | 2.0 | |
55-5 (Pro → Arg) | 8.0 | 6, 16 |
55-6 (Pro → Leu) | 4.0 | 6, 10 |
Isolation of an folP-disrupted M. smegmatis strain carrying the M. leprae folP1 with mutation 48-4 was unsuccessful.