TABLE 5.
Occurrence of Plasmodium falciparum isolates carrying multiple mutations across 4 genes associated with drug resistanced
| pfcrt haplotype | pfdhfr haplotype | No. of isolates with: |
|||
|---|---|---|---|---|---|
| Double gene mutation (pfcrt + pfdhfr only)a | Triple gene mutation (+pfmdr1) |
||||
| NYSND | YYSND | NFSDD | |||
| CVMNK | NCSI | 1 | 0 | 1 | 0 |
| NRNI | 14 | 1 | 1 | 0 | |
| NCNIa | 0 | 0 | 0 | 0 | |
| CVIET | NCSI | 0 | 0 | 0 | 0 |
| NRNI | 1b | 0 | 1b | 0 | |
| NCNIa | |||||
| SVMNT | NCSI | 2 | 0 | 2 | 1 |
| NRNI | 114 | 3 | 100c | 3 | |
| NCNI | 1 | 0 | 0 | 0 | |
Assayed only for pfcrt and pfdhfr due to an inadequate sample volume.
Sample with P. falciparum carrying both the CVIET and SVMNT mutations.
Four of these isolates were also carrying the K540E mutation, while all other P. falciparum samples carried the 540K allele of the pfdhps gene.
Wild-type alleles of pfcrt, pfdhfr, and pfmdr1 are those in boldface type. Allele mutations are underlined. the pfcrt CVMNK, CVIET, and SVMNT haplotypes correspond to codons 72 to 76. The pfdhfr NCSI, NRNI, and NCNI haplotypes correspond to codons 51, 59, 108, and 164. The pfmdr1 NYSND, YYSND, and NFSDD haplotypes correspond to codons 86, 184, 1034, 1042, and 1246.