FIG. 3.

WBA of PNU-100480 (left) and linezolid (right). Zero on the vertical axis indicates bacteriostasis; negative values indicate killing. (A) Values at discrete time points after dosing. (B) Cumulative activity over 24 h. (C) Concentration-activity relationship. Drug concentrations have been reduced by half to account for dilution in whole-blood culture. Values for linezolid at 600 mg BID are based on published PK data and the relationship between concentration and activity that was established from the data in panel C. The cumulative bactericidal activity of PNU-100480 at 600 mg BID exceeded that of any other oxazolidinone dosing schedule tested. This was significantly augmented by the addition of pyrazinamide.