TABLE 3.
Confirmation of powder compoundsa
| Sample name | ATP content |
IC50 (μM) by enumeration method | |
|---|---|---|---|
| IC50 (μM) | % efficacy | ||
| Metronidazole | 1.6 | 99.7 | 2.2 |
| Fumagillin | 0.002 | 98.9 | 0.003 |
| Bortezomib | 0.06 | 98.5 | 0.13 |
| Decitabine | 0.15 | 95.1 | 0.07 |
| Carbadox | 0.24 | 99.4 | 0.29 |
| Nitarsone | 0.9 | 99.6 | 1.2 |
| BTO-1 | 2.0 | 99.1 | 9.3 |
| GW9662 | 12.7 | 99.2 | 32.9 |
| Hydroxocobalamin acetate | 78.3 | 98.4 | 54.2 |
a
The novel anti-Giardia compounds were purchased as powder samples and tested against the GS isolate using both the ATP content and trophozoite enumeration methods.