Skip to main content
. 2010 Oct 18;55(2):608–614. doi: 10.1128/AAC.00920-10

TABLE 3.

Inhibitory activities of OFX and MXF against gyrase complexes reconstituted with WT H37Rv, the FQs clinical strain, and the gyrA Ala74Ser variant

Strain Amino acid change in DNA gyrasea
 MIC (μg/ml)
 IC50 (μg/ml)
gyrA
 gyrB OFX MXF OFX MXF
E21Q S95T G668D A74S Other
WT H37Rv ND ND ND ND ND ND 0.5 0.25 1.92 0.98
FQs clinical strain + + + ND ND ND 0.5 0.25 3.30 1.62
Clinical strain harboring the Ala74Ser mutation in gyrA + + + + ND ND 8.0 4.0 15.56 14.37
a

+, Detected; ND, not detected.