TABLE 1.
Pharmacokinetic-pharmacodynamic values for the free (non-protein-bound) fraction of moxifloxacin obtained in the dose fractionation studies
| Total moxifloxacin dose (mg/day) | Pharmacokinetic-pharmacodynamic valuea for moxifloxacin: |
|||||
|---|---|---|---|---|---|---|
| Given once daily |
Given as a continuous infusion |
|||||
| fCmax/MIC | fAUC/MIC | fT>MIC (h) | fCmax/MIC | fAUC/MIC | fT>MIC (h) | |
| First expt | ||||||
| 50 | 4.8 | 63.5 | 24 | 2.6 | 63.5 | 24 |
| 100 | 9.6 | 127.0 | 24 | 5.3 | 127.0 | 24 |
| 150 | 14.4 | 190.5 | 24 | 7.9 | 190.5 | 24 |
| 200 | 19.2 | 254.0 | 24 | 10.9 | 254.0 | 24 |
| 250 | 24.0 | 317.5 | 24 | 13.2 | 317.5 | 24 |
| Second expt | ||||||
| 100 | 9.6 | 127.0 | 24 | 5.3 | 127.0 | 24 |
| 150 | 14.4 | 190.5 | 24 | 7.9 | 190.5 | 24 |
| 175 | 16.8 | 222.2 | 24 | 9.3 | 222.2 | 24 |
| 200 | 19.2 | 254.0 | 24 | 10.9 | 254.0 | 24 |
a
f, free (non-protein bound).