TABLE 3.
MICs and QRDR mutations in mutants of Y. pestis ΔCO92 amplified with suboptimal moxifloxacin regimens in the moxifloxacin dose range studiesa
| Mutant source | Moxifloxacin MIC (mg/liter) | Mutation in GyrA |
|---|---|---|
| Mutation frequency isolates | 1 | Ser83Ile or Ser83Arg |
| Mutation frequency isolates | 0.5 | Asp87Tyr or Gly81Cys |
| Control, day 3 | 0.25 | NMb |
| Control, day 10 | 1 | Asp82Gly |
| 50 mg/day, days 3, 4, and 10 | 1 | Ser83Arg |
| 100 mg/day, days 3, 6, and 10 | 0.5-1 | Asp82Gly |
a
The MIC of moxifloxacin for the wild-type parent isolate was 0.06 mg/liter. Neither the wild type nor the mutants had any mutations in the QRDRs of GyrB, ParC, and ParE.
b
NM, no mutation identified.