TABLE 3.
Voriconazole concentrations in 128 tissue samples from eight patients
| Patient | VRC concn (μg/ml) ina: |
|||||
|---|---|---|---|---|---|---|
| Lung | Brain | Liver | Spleen | Kidney | Myocardium | |
| 1b | 0.74 (0.72-0.76) | <0.25 | 2.14 (1.86-2.42) | 1.31 (1.29-1.34) | 1.97 (1.69-2.26) | <0.25 |
| 2 | 4.44 (3.64-5.20) | 1.67 (1.38-2.06) | 6.28 (6.22-6.34) | 5.93 | 6.05 (5.99-6.10) | 2.04 (1.96-2.13) |
| 3 | 6.57 (6.12-6.78) | 6.54 (5.77-6.95) | 19.83 (19.58-20.08) | 5.72 (5.60-5.84) | 4.88 (4.83-4.92) | 7.55 (6.53-8.57) |
| 4 | 1.98 (1.47-2.04) | 3.36 (3.08-3.56) | 4.21 (3.67-4.76) | 2.95 (2.92-2.99) | 6.89 (6.84-6.93) | 2.44 (2.27-2.62) |
| 5 | 5.94 (4.14-7.86) | 2.27 (2.25-3.79) | 8.69 (7.44-9.95) | 2.22 (2.22-2.22) | 2.89 (2.76-3.02) | 3.17 (3.10-3.23) |
| 6 | 6.59 (4.74-9.38) | 2.72 (2.57-3.35) | 2.98 (2.83-3.12) | 6.10 (5.46-6.74) | 8.89 (8.64-9.13) | 13.47 (13.11-13.84) |
| 7 | 20.26 (19.82-20.87) | 27.72 (26.78-34.70) | 35.53 (35.04-36.03) | 18.73 (17.98-19.47) | 13.58 (11.10-16.05) | 25.79 (25.54-26.05) |
| 8 | 13.68 (12.04-15.07) | 20.09 (17.43-23.13 | 40.04 (37.77-42.31) | 14.27 (13.71-14.83) | 14.81 (13.55-16.08) | 19.85 (19.53-20.18) |
| Median | 6.26 | 3.41 | 6.89 | 5.60 | 6.47 | 7.55 |
| Interquartile range | 7.87 | 16.72 | 24.16 | 11.49 | 6.19 | 16.91 |
a
Shown are median VRC concentrations (with ranges in parentheses). Multiple sampling was performed from different sites as follows: lung, four samples (upper and lower lobe, left and right); brain, five samples (cortex, hippocampus, nucleus caudatus, medulla oblongata, and cerebellum); liver, two samples from different sites; spleen, two samples from different sites; kidney, two samples (left and right); and myocardium, two samples (ventricular septum and anterior wall).
b
Patient 1 received only a single dose of VRC.