. 2010 Nov 15;55(2):729–737. doi: 10.1128/AAC.01173-10

TABLE 5.

Effects of signature envelope substitutions on BMS-488043 sensitivity

Type of sensitivity change, mutagenesis, and subject	Fold change with:
Type of sensitivity change, mutagenesis, and subject	V68A	L116I	S375I	S375N	M426L
Increase, mutant to wild type
19		52
10			>32
25				229
4					176
27					791
30					>74
Decrease, wild type to mutant
15	28	20	39	155	1,308
22	6	3	166	61	259
23	11	67	120	204	829