TABLE 5.

In vitro quinine sensitivities of isolates with various combinations of polymorphisms^a

Parameter	Result for isolates with polymorphisms at codons 86 and 1246 and the indicated no. of DNNND repeats:
	Mutant			WT
	1	2	3	1	2	3
No. of isolates	33	49	42	4	10	5
Median IC50 (nM)	115	151	124	111	111	55
25th-75th percentile IC50 (nM)	33-275	60-292	30-249	42-200	18-238	27-182
Geometric mean IC50 (nM)	99	129	90	90	75	61
95% CIb (nM)	65-153	96-175	64-128	20-410	29-194	18-206

^aIn vitro IC₅₀s are shown for parasites with mutant or wild-type (WT) sequences at pfmdr1 codons 86 and 1246 and with the indicated number of pfnhe1 repeats.

^bCI, confidence interval.