FIG. 3.

Serum and lung homogenate cytokine levels following intranasal Klebsiella pneumoniae infection in mice. Animals (2 to 4 mice/group) were either dosed subcutaneously with doripenem (blue circles), meropenem-cilastatin (green triangles), or imipenem-cilastatin (red squares) at 1.5, 3, 6, 9, and 12 h postinfection with Klebsiella pneumoniae on day 1 or remained untreated (black circles). Each data point represents the cytokine level of a single mouse, and the bar represents the group mean. Statistical analysis consisted of a one-way ANOVA with Tukey's posttest (*, P < 0.05; **, P < 0.01; ***, P < 0.001, relative to the untreated control at the same time point).