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Brown-Hopps stain of lung sections at 12 h postinfection. Magnification, ×100. (a) Untreated control animals, free organisms, and organisms in phagocytic cells. (b) Doripenem treatment. Alveolar macrophages contain bacteria. Mixed infiltrates of macrophages and neutrophils. (c) Meropenem treatment. Alveolar hemorrhage and macrophages in alveoli. (d) Imipenem treatment. Alveoli filled with neutrophils and macrophages containing organisms.
