FIG. 6.

Effector functions of macrophages are altered depending on the agglutination state of infectious particles. (A) Measurements of H. capsulatum growth inhibition by macrophages revealed different outcomes depending on the agglutinate size and the subclass of MAb used (P < 0.05). (B) Nitric oxide release by macrophages significantly depended on the agglutinate size and MAb subclass used (P < 0.05). The results shown in panels A and B are averages from three independent experiments. (C) Correlation of aggregation-related killing efficacy and nitric oxide levels produced by macrophages show that nitric oxide might be the principal antifungal-related molecule (P = 0.05).