TABLE 2.
IL-6-dependent urothelial transcriptome upregulation
| Functional category and Affymetrix ID | Fold change | Max P value | Gene description |
|---|---|---|---|
| Cytokine/chemokine response | |||
| Cfa.54.1.S1_s_at | 4.73 | 0.000060 | Tumor necrosis factor |
| CfaAffx.11741.1.S1_s_at | 2.92 | 0.000040 | Interleukin 1 beta |
| Cfa.3554.1.S1_at | 2.78 | 0.000040 | Interleukin 1 beta |
| CfaAffx.21295.1.S1_at | 2.84 | 0.000040 | Chemokine (C-C motif) receptor-like 2 |
| Cfa.14352.1.A1_at | 2.68 | 0.000040 | Chemokine (C-C motif) ligand 3 |
| Cfa.15815.1.S1_s_at | 2.05 | 0.000080 | Chemokine (C-C motif) ligand 3 |
| Cfa.16590.1.S1_s_at | 2.36 | 0.000040 | Chemokine (C-X-C motif) ligand 10 |
| Cfa.16590.1.S2_at | 2.22 | 0.000040 | Chemokine (C-X-C motif) ligand 10 |
| CfaAffx.1705.1.S1_at | 2.20 | 0.000046 | Gamma interferon-inducible protein 47 |
| Cfa.3528.1.S1_s_at | 2.14 | 0.000156 | Interleukin-6 |
| Matrix metallopeptidases | |||
| Cfa.3447.1.S1_s_at | 3.28 | 0.000040 | Matrix metallopeptidase 3 |
| CfaAffx.23166.1.S1_s_at | 3.10 | 0.000040 | Matrix metalloproteinase 1 |
| CfaAffx.23166.1.S1_at | 2.62 | 0.000040 | Matrix metalloproteinase 1 |
| Cfa.3597.1.S1_at | 2.13 | 0.000260 | Matrix metallopeptidase 2 |
| CfaAffx.14851.1.S1_s_at | 2.03 | 0.000046 | Matrix metallopeptidase 2 |
| Mediators of cell adhesion | |||
| Cfa.3868.1.S1_at | 3.20 | 0.000040 | Selectin E |
| CfaAffx.23326.1.S1_s_at | 2.51 | 0.000040 | Selectin E |
| CfaAffx.23464.1.S1_s_at | 3.00 | 0.001104 | Dermatopontin precursor |
| Cfa.6133.1.S1_at | 2.02 | 0.000040 | Dermatopontin precursor |
| CfaAffx.13511.1.S1_at | 2.93 | 0.000040 | Immunoglobulin superfamily, member 10 |
| Cfa.3983.1.A1_s_at | 2.45 | 0.000260 | Immunoglobulin superfamily, member 10 |
| Glycosaminoglycan production | |||
| CfaAffx.27384.1.S1_s_at | 2.46 | 0.000054 | Heparan sulfate d-glucosaminyl 3-O-sulfotransferase 3A1 |
| CfaAffx.2351.1.S1_at | 2.14 | 0.000334 | Hyaluronan synthase 2 |
| CfaAffx.24924.1.S1_at | 2.38 | 0.000060 | Colony-stimulating factor 3 isoform b precursor |
| CfaAffx.4373.1.S1_s_at | 2.21 | 0.000040 | Bone morphogenetic protein 5 precursor (BMP-5) |
| Cfa.9659.1.A1_at | 2.16 | 0.000104 | Vascular smooth muscle cell growth-promoting factor |
| Growth and differentiation factors | |||
| Cfa.12671.1.A1_at | 2.14 | 0.000546 | Signaling lymphocyte activation molecule family member 7 |
| CfaAffx.5498.1.S1_at | 2.12 | 0.000040 | CXCL7; leukocyte-derived growth factor; macrophage-derived growth factor |
| CfaAffx.18191.1.S1_s_at | 2.11 | 0.002402 | Myeloid cell nuclear differentiation antigen |
| CfaAffx.5548.1.S1_at | 2.10 | 0.000546 | Epiregulin |
| Cfa.3484.1.S1_at | 2.05 | 0.002972 | Progesterone receptor |
| Negative regulators | |||
| CfaAffx.1046.1.S1_at | 2.34 | 0.002972 | Urokinase inhibitor |
| CfaAffx.2230.1.S1_s_at | 2.31 | 0.000040 | Thrombospondin 2 precursor |
| CfaAffx.1632.1.S1_s_at | 2.26 | 0.000040 | Radiation-inducible immediate-early gene IEX-1 |
| CfaAffx.13597.1.S1_s_at | 2.09 | 0.000614 | Chondroitin sulfate proteoglycan 2 |
| CfaAffx.25712.1.S1_at | 2.02 | 0.000040 | Jumonji domain-containing 3 |
| Miscellaneous | |||
| CfaAffx.13553.1.S1_at | 2.83 | 0.001932 | Succinate receptor 1 |
| Cfa.13912.1.A1_at | 2.35 | 0.000104 | Ribonucleotide reductase small chain |
| Cfa.3973.1.A1_at | 2.35 | 0.000984 | Proteasome alpha 3 subunit isoform 2 |
| Cfa.1370.1.A1_at | 2.33 | 0.000040 | Solute carrier family 2 |
| Cfa.825.1.S2_at | 2.10 | 0.000040 | Solute carrier family 2 |
| CfaAffx.13491.1.S1_at | 2.22 | 0.000482 | G-protein-coupled receptor 171 |
| CfaAffx.4930.1.S1_s_at | 2.21 | 0.000070 | Alpha 1 type XII collagen short-isoform precursor |
| CfaAffx.1247.1.S1_s_at | 2.18 | 0.000040 | Vanin 1 |
| Cfa.6170.1.A1_at | 2.09 | 0.001384 | GMP-PDE gammaa |
| CfaAffx.14532.1.S1_at | 2.08 | 0.000040 | Nuclear receptor subfamily 4, group A, member 2 |
| Cfa.1416.1.A1_at | 2.03 | 0.000876 | Proenkephalin A precursor |
| Cfa.3589.1.S1_s_at | 2.03 | 0.000070 | Caspase 4, apoptosis-related cysteine peptidase |
a
PDE, phosphodiestrase.