FIG. 7.

CCR2 dependence of iDC recruitment. WT and CCR2^−/− C57BL/6 mice were infected with parent and ΔyopM Y. pestis KIM5 and analyzed as described in the legend for Fig. 6 for iDCs in spleens and livers on day 3. U, uninfected mice; P/WT, WT mice infected with parent Y. pestis; M/WT, WT mice infected with ΔyopM Y. pestis; P/CCR2^−/−, CCR2^−/− mice infected with the parent strain; M/CCR2^−/−, CCR2^−/− mice infected with the ΔyopM strain. Each datum point represents the average of values from 19 mice. The error bars indicate the standard deviations. In comparisons between WT and CCR2^−/− groups, ψ, P < 0.05, and ψψ, P < 0.01, for mice infected with ΔyopM Y. pestis; In comparisons between groups of mice infected with parent and ΔyopM Y. pestis, **, P < 0.01 for WT mice.