TABLE 2.
Chimeric RNA from clonal HPV-16-positive keratinocytes
| Clone no. | Splice structurea | GenBank accession no.b | Chromosome | Gene locusb |
|---|---|---|---|---|
| HTE-01 | 880^3358-3548-human chromosome 8 | NT_008046.16 | 8 | c-myc |
| HTE-02 | 880^human chromosome 5 | NT_006713.15 | 5 | Integrin α-2 |
| HTE-03 | 880^human chromosome 2 | NW_001838868 | 2 | Unknown |
| HTE-04 | 880^3358-3469-human chromosome 2 | NW_001838863.1 | 2 | Unknown |
| HTE-05 | 880^human chromosome 8 | NT_008046.16 | 8 | c-myc |
| HTE-06 | 880^human chromosome 3 | NT_005612.16 | 3 | Plexin D1 |
| HTE-07 | 880^human chromosome 1 | NT_004487.19 | 1 | Monooxygenase 3, isoform 1 |
| HTE-08 | 880^human chromosome 8 | NT_008046.16 | 8 | c-myc |
| HFK-01 | 880^human chromosome 4 | NT_016354.9 | 4 | FAP-1/PTPN13 |
| HFK-01 | 880^3358-3633-human chromosome 4 | NT_016354.9 | 4 | FAP-1/PTPN13 |
| HFK-02 | 880^human chromosome 12 | NW_001838060.2 | 12 | Methionine sulfoxide reductase B3 |
| HFK-03 | 880^human chromosome 4 | NT_016354.9 | 4 | FAP-1/PTPN13 |
| HFK-04 | 880^human chromosome 6 | NW_001838981 | 6 | |
| HFK-05 | 880^human chromosome 6 | NT_007299.13 | 6 | |
| HFK-06 | 880^human chromosome 7 | AC005246 | 7 | Atrophin-1-interacting gene |
| HFK-07 | 880^3358-3776^human chromosome 6 | NT_025741.15 | 6 | Laminin alpha 2 antisense |
| HFK-08 | 880^human chromosome 12 | NT_029419.12 | 12 | HMG AT-hook, isoform b |
| HFK-09 | 880^human chromosome 6 | NT_025741.15 | 6 | Laminin alpha 2, isoform b |
| HFK-10 | 880^human chromosome 1 | NT_032977.9 | 1 | |
| HFK-11 | 880^human chromosome 12 | NW_001838060.2 | 12 | Methionine sulfoxide reductase B3 |
| HFK-12 | 880^human chromosome 12 | NW_001838060.2 | 12 | Methionine sulfoxide reductase B3 |
| HFK-13 | 880^human chromosome 8 | NW_001839136.1 | 8 | Protein serine kinase H2 |
| HFK-14 | 880^human chromosome 10 | NT_030059.13 | 10 | |
| HFK-15 | 880^human chromosome 8 | NT_008046.16 | 8 | c-myc |
| HFK-16 | 880^3358-3631-human chromosome 9 | NT_008470.19 | 9 | |
| HFK-17 | 880^human chromosome 4 | NT_016354.19 | 4 | BMP-2 inducible kinase, isoform a |
| HFK-18 | 880^human chromosome 12 | NT_029419.12 | 12 | HMG AT-hook, isoform b |
| HFK-19 | 880^human chromosome 8 | NT_008046.16 | 8 | c-myc |
| HFK-20 | 880^3358-3489^human chromosome 5 | NT_034772.6 | 5 | Fer tyrosine kinase |
| HFK-21 | 880^human chromosome X | NT_079573.4 | X | |
| HFK-22 | 880^human chromosome 12 | NW_001838060.2 | 12 | HIV-1 Rev binding protein 2 |
| HFK-23 | 880^human chromosome 13 | NT_024524.14 | 13 |
a
Chimeric mRNA-derived amplification products from HPV-immortalized human tonsillar (HTE) or foreskin (HFK) keratinocytes were sequenced to determine structure.
b
Chimeric mRNA-derived amplification products were compared to the GenBank database by BLASTN search; for example, FAP-1 is FAS-activated phosphatase 1 (PTPN13). Clonal HPV+/HTE cultures were derived from 3 independent experiments, while HPV+/HFK clones were derived from 12 independent experiments.