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The captured repertoire of VACV-specific antibodies mirrors the natural genetic diversity of a human antibody response. The frequencies of IGHV (left panel) and IGKV (right panel) gene usage in the VACV-specific antibody repertoire were calculated based on the genetic origin of each of the 89 confirmed VACV-specific antibodies (Table 2). The highly homologous gene pair IGKV1-12/IGKV1D-12 was for clarity treated as a single entity.
