FIG. 3.

Transitional memory CD8⁺ cells exhibit maximal CNAR activity. Shown are staining profiles (left) and anti-HIV activities (right) of CD8⁺ cells that were separated into distinct populations based on the expression of CD45RA and CD62L (A), CD45RA and CCR7 (B), CD57 and CD11b (C), CD28 and CD11b (D), CD57 and CD28 (E), CD27 and CD28 (F), and CD45RA, CD27, and CD28 (G). Suppression data are shown for CD8⁺ cell/infected CD4⁺ cell coculture ratios of 0.25:1 (G only), 0.5:1, and 1:1 (left to right). Results are representative of at least 2 independent experiments with different CD8⁺ cell sources.