FIG. 3.

Localization of neutralizing MAb 2c epitopes on the gB crystal structure (Protein Data Bank [PDB] accession no. 2GUM). The ribbon diagram of the gB trimer shows one protomer with functional domains colored (domain I in cyan, domain II in green, domain III in yellow, domain IV in orange, and domain V in red). The other two protomers are shown in dark and light gray. Asterisks indicate the fusion loops of protomers highlighted in gray; fusion loops of the colored protomer are not visible. The mapped residues of the discontinuous MAb 2c epitope, F₁₇₅ to A₁₉₀ and F₃₀₀ to E₃₀₅, are indicated in surface representation by dark blue for the color-coded protomer and by rose for both other protomers.