Table 1.

Screening of rearrangement conditions.

Entry	Reaction conditions					Yield (%)a
	Starting material	Reagent / condition type	Solvent	T (°C)	Time (h)
1	(R)-isomer	-	-	110	3	27
2	(R)-isomer	-	toluene	110	48	70
3	(R)-isomer	-	o-xylene	140	48	64
4	(R)-isomer	-	ethylene dichloride	80	72	40 + 20c
5	(R)-isomer	-	CHCl3	65	72	25
6	(R)-isomer	-	toluene	110	48	70
7	(R)-isomer	boric acid (1.0 equiv)	toluene (u/N2)	110	24	65
8	(R)-isomer	boric acid (1.0 equiv)	toluene	110	24	65
9	(R)-isomer	boric acid (0.5 equiv)	toluene	110	48	60
10	(R)-isomer	MeSO3H	toluene	110	1	27
11	(R)-isomer	tartaric acid	toluene	110	24	38
12	(R)-isomer	citric acid	toluene	110	24	16
13	(R)-isomer	p-TSA	toluene	110	24	38
14	(R)-isomer	sonication	CHCl3	RT	2	34b
15	(R)-isomer	sonication	DMF	RT	1	2b
16	(R)-isomer	sonication	ethyl acetate	RT	1	5b
17	(R)-isomer	sonication + boric acid	CHCl3	RT	1	16b
18	(R)-isomer	sonication + p-TSA	CHCl3	RT	0.5	23b
19	(R)-isomer	-	toluene	RT	144	3
20	(R)-isomer	-	CHCl3	RT	144	21b
21	(R)-isomer	-	MeOH	RT	144	3b
22	(R)-isomer	benzoyl peroxide	toluene	110	48	60
23	(R)-isomer	TEMPO	toluene	RT - 110	40	9b
24	(R)-isomer	2,6-di-tert-butylphenol	toluene	110	24	75
25	(S)-isomer	-	toluene	110	48	70
26	(R)-isomer	MW 150 Watt	DMF	150	0.5	70

^aIsolated yield, ^b% conversion in HPLC, ^crecovered starting material with SOR +5°