Table.
Relevant laboratory parameters in relation to normal and abnormal haemoglobin variants
| Presumptive HPLC Diagnosis | No. of cases (%) | Hb (g/dl) | MCV (fl) | MCH (pg) | MCHC (%) | RBC count (x106/μl) | RDW-SD (%) | Hb A (%) | Hb F (%) | HbA2 (%) | Variant Hb (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal | 553 (69.1) | 9.6 (2.7) | 83.3 (10.7) | 25.1 (4.9) | 30.6 (3.8) | 3.82 (0.8) | 47.6 (10.4) | 87.4 (4.2) | 0.2 (0.5) | 2.9 (0.4) | |
| β-Thal trait | 145 (18.1) | 10.3 (2.1) | 68.6 (7.4) | 20.5 (2.6) | 28.3 (1.8) | 5.06 (0.9) | 35.7 (8.1) | 83.2 (2.1) | 1.0 (1.3) | 5.5 (0.6) | |
| β-Thal major/Intermedia | 23 (2.9) | 5.4 (1.7) | 74.9 (8.5) | 23.3 (3.7) | 31.1 (3.2) | 2.41 (0.9) | 55.3 (14.4) | 39.2 (30.5) | 52.5 (35.2) | 3.7 (1.5) | |
| Sickle cell trait | 11 (1.4) | 11.6 (1.8) | 84.3 (3.4) | 26.7 (2.3) | 31.7 (2.3) | 4.45 (0.54) | 45.3 (16.2) | 52.7 (3.8) | 2.3 (3.6) | 3.3 (0.3) | 36.3 (4.8) |
| HbS/β-thal | 6 (0.8) | 7.6 (1.2) | 75.2 (9.0) | 21.8 (2.0) | 29.2 (2.6) | 3.49 (0.6) | 49.5 (15.5) | 4.6 (1.8) | 18.3 (8.4) | 4.5 (0.6) | 71.7 (5.8) |
| Homozygous Sickle cell ds | 4 (0.5) | 8.3 (1.9) | 90.5 (9.7) | 29.5 (3.4) | 32.7 (0.9) | 2.8 (0.6) | 66.8 (6.6) | 8.5 (13.7) | 18.3 (8.2) | 2.4 (0.5) | 74.5 (6.7) |
| HbE-trait | 9 (1.1) | 11.4 (2.3) | 82.3 (4.4) | 26.2 (1.5) | 31.6 (1.1) | 4.3 (0.7) | 41.1 (5.8) | 61.9 (1.9) | 1.6 (3.7) | -- | 27.8 (3.4) |
| HbE/β-thal | 10 (1.3) | 6.2 (1.1) | 63.9 (7.7) | 19.3 (2.7) | 30.1 (1.4) | 3.2 (0.54) | 47.9 (9.8) | 18.1 (22.4) | 21.7 (12.2) | -- | 52.3 (17.6) |
| Homozygous HbE ds | 1 (0.1) | 7.5 | 63 | 20.4 | 32.3 | 3.68 | 31.4 | 3.7 | 4.5 | -- | 78.2 |
| HbD-Punjab trait | 7 (0.9) | 8.1 (2.4) | 70.3 (16.1) | 20.4 (7.4) | 28.3 (3.9) | 3.98 (0.42) | 42.3 (12.5) | 55.7 (4.1) | 0.5 (0.4) | 1.7 (0.4) | 34.6 (4.1) |
| HbD/β-thal | 1 (0.1) | 13.3 | 67.1 | 21.1 | 31.5 | 6.29 | 34.1 | 3.7 | 2.3 | 4.7 | 83 |
| Double hetero HbSD ds | 1 (0.1) | 8.8 | 90.2 | 27.8 | 30.9 | 3.16 | 60.8 | 2.2 | 8.6 | 3.2 | 41.9/41 |
| HbQ-India trait | 3 (0.4) | 12.5 (1.6) | 80.7 (7.2) | 26.6 (2.1) | 32.9 (0.4) | 4.69 (0.2) | 37.9 (1.1) | 71.5 (1.7) | 0 | 2.0 (1.7) | 18.5 (0.2) |
| Hb-Lepore trait | 1 (0.1) | 9.9 | 72.2 | 22.9 | 31.7 | 4.32 | 32.3 | 70.5 | 4.4 | -- | 16.4 |
| α-thal trait | 11 (1.4) | 7.6 (1.9) | 63.8 (6.9) | 16.8 (2.8) | 26.3 (2.6) | 4.66 (0.9) | 39.0 (11.7) | 85.9 (3.4) | 0.3 (0.4) | 2.2 (0.3) | |
| δβ-thal trait | 6 (0.8) | 11.1 (2.2) | 69.0 (7.7) | 20.8 (2.7) | 30.1 (0.9) | 5.36 (1.0) | 40.7 (7.2) | 72.5 (2.4) | 13.3 (4.3) | 2.8 | |
| HPFH | (0.1) | 11.1 | 73.5 | 23.9 | 32.6 | 4.64 | 39.9 | 62.4 | 31.5 | 2.7 | |
| HbD-Iran trait | 3 (0.4) | 7.4 (4.3) | 64 (13.7) | 17.7 (7.1) | 26.9 (4.8) | 3.99 (0.8) | 32.6 (3.8) | 49.6 (1.9) | 0.8 (0.3) | -- | 40.6 (2.6) |
| Hb-H disease | 1 (0.1) | 4.9 | 84.0 | 20.7 | 24.6 | 2.3 | 45 | 87.7 | 0.4 | 2.2 | -- |
| HbJ-Meerut trait | 1 (0.1) | 11.9 | 91.1 | 30.1 | 33.1 | 3.95 | 45.9 | 65.4 | 0.5 | 2.5 | 26.5 |
All figures mentioned are mean ± SD. Two cases with high HbA1c are not mentioned in this Table.
Hb, haemoglobin; MCV, mean cell volume; MCH, mean cell haemoglobin; MCHC, mean cell haemoglobin concentration; RBC, red blood cell; RDW, red cell distribution width; Thal, thalassaemia