. Author manuscript; available in PMC: 2011 Jan 27.

Published in final edited form as: Clin Res Regul Aff. 2009 Jan 1;26(3):65–72. doi: 10.1080/10601330903200684

Table 4.

Urinary pharmacokinetic parameters of VVACV and the generated VACV and ACV following i.v. administration of VVACV in rats.

pK parameter	VVACV	VACV	ACV
Percent of dose recovered (%)	31.81 ± 6.22	10.72 ± 1.99	48.57 ± 16.47
Cl_r (ml/min/kg)	124.19 ± 48	18.61 ± 1.94	19.94 ± 7.21
Cl_nr (ml/min/kg)	233.83 ± 41.69	162.58 ± 25.25	21.2 ± 6.16
k (hr⁻¹)	1.73 ± 0.22	1.6 ± 0.61	1.72 ± 0.51
k_e (hr⁻¹)	0.61 ± 0.30	0.19 ± 0.05	1.16 ± 0.52
k_m (hr⁻¹)	1.11 ± 0.12	1.40 ± 0.57	0.55 ± 0.24

(Values are represented as mean ± S.D, n=4)