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Plasma pharmacokinetic parameters of VVACV and the generated VACV and ACV following oral administration of VVACV in rats.
| pK parameter | VACV | ACV |
|---|---|---|
| Tmax (min) | 15 | 15 |
| Cmax (µM) | 3.14 ± 0.28 | 25.49 ± 1.71 |
| AUC0−t (Min*µM) | 82.51 ± 6.81 | 808.56 ± 72.06 |
| AUC0−inf (min*µM) | 89.28 ± 4.78 | 810.77 ± 73.39 |
| λz (min−1) | 0.03 ± 0.008 | 0.01 ± 0.008 |
(Values are represented as mean ± S.D, n=4)
