A schematic diagram illustrating the role of G6PD in regulating CA contractility. A flow diagram illustrates that activation of PKC, most likely PKCδ, by depolarization or G-coupled receptors phosphorylate G6PD, and stimulated G6PD, either directly or via inducing changes in NADPH redox, modulates CA contraction evoked by Ca2+-dependent phosphorylation of MLC. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article at www.liebertonline.com/ars).