Extensively drug-resistant (XDR) tuberculosis (TB) cases averted during 2007–2012 in Tugela Ferry, South Africa, with use of combinations of available strategies [43]. Efficacy of rapidly available combinations of strategies to reduce nosocomial transmission of XDR-TB. 5 pt, isolation of patients in groups of 5 patients; LOS, reduction in mean duration of stay to 5 days; Mask, both staff N95 respirators and patient masks with adherence enforcement; MODS, microscopic observed drug-susceptibility assay; VCT, voluntary counseling and testing of admitted patients, with subsequent antiretroviral therapy to those who qualify; Vent, improvements in natural ventilation.