Table 3.

HRs of Incident AD Associated With DP Score 2

Modela	No. of Cases/Total at Baseline	DP Score 2 Tertileb	HR (95% CI)	P Value	P Trendc
Model 1	253/2148	Lowest	1 [Reference]
		Middle	0.73 (0.56–0.97)	.03
		Highest	0.54 (0.39–0.75)	<.001	<.001
Model 2	251/2141	Lowest	1 [Reference]
		Middle	0.72 (0.54–0.95)	.02
		Highest	0.59 (0.42–0.82)	.002	.001
Model 3	211/1691	Lowest	1 [Reference]
		Middle	0.81 (0.59–1.12)	.20
		Highest	0.62 (0.43–0.89)	.01	.01
Supplementary Analysis
Model 2 and alcohol	251/2141	Lowest	1 [Reference]
		Middle	0.70 (0.52–0.93)	.01
		Highest	0.59 (0.42–0.82)	.002	.002
Model 2 and nutrient supplements	251/2141	Lowest	1 [Reference]
		Middle	0.72 (0.54–0.96)	.03
		Highest	0.60 (0.43–0.85)	.003	.002
Model 2 and alcohol and nutrient supplements	251/2141	Lowest	1 [Reference]
		Middle	0.70 (0.53–0.93)	.02
		Highest	0.60 (0.43–0.85)	.003	.002
Model 2 and baseline CDRd	204/1758	Lowest	1 [Reference]
		Middle	0.66 (0.48–0.91)	.01
		Highest	0.64 (0.44–0.92)	.02	.007

Abbreviations: AD, Alzheimer disease; CI, confidence interval; CDR, Clinical Dementia Rating; DP, dietary pattern; HR, hazard ratio.

^aModel 1: unadjusted. Model 2: adjusted for recruitment cohort, age, education, ethnicity, and sex. Model 3: adjusted for covariates in model 2 and smoking status, body mass index, caloric intake, comorbidity index, and APOE ε4 genotype.

^bThe tertiles were defined based on the distribution of the DP score 2 among participants who remained without dementia during the follow-up.

^cP trend was obtained by entering the tertile terms as an ordinal variable in the Cox model.

^dLimited to subjects with more than 2 years of follow-up.