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. 2011 Jan 27;6(1):e14605. doi: 10.1371/journal.pone.0014605

Figure 3. Amelioration of high-fat diet-induced obesity in Rcan2 −/− mice.

Figure 3

(A, B) Growth curves of 9 Rcan2 +/+ and 10 Rcan2 −/− males (A) and 5 Rcan2 +/+ and 5 Rcan2 −/− females (B) mice fed on a high-fat diet for 12 weeks. ***: P<0.0001. (C) Mean weight of epididymal and retroperitoneal white adipose tissue (EWAT and RWAT, respectively) in four Rcan2 +/+ and Rcan2 −/− males fed on a high-fat diet for 12 weeks. (D) Mean weight of liver in four Rcan2 +/+ and Rcan2 −/− males fed on a high-fat diet for 12 weeks. (E) Glucose tolerance test. n = 6 in each group. (F) Insulin tolerance test. n = 6 in each group. All values are given as mean ± s.e.m. *: P<0.05; **: P<0.01. Filled circles/columns indicate Rcan2 +/+ mice; open circles/columns, Rcan2 −/− mice.