Figure 1. Scheme of the topogenic domains in PrP. Topogenic sequences shown are NH₂-terminal signal sequence (signal), the potential membrane-spanning domain (TM1) and glycosylation site (CHO).

Amino acid positions are shown below the diagram. The amino acid sequences of wild type and the mutated PrPs used in this study are illustrated below. The amino acid substitutions in PrP mutants are indicated by black, italic and underlined letter.