Table 1. Patient characteristics.

	Isolated GHD (n = 16)		MPD (n = 5)		TOTAL (n = 21)
Neonatal symptoms	n'	Percentage	n'	Percentage	n'	Percentage
Breech delivery	2	12.5% (CI 0–29)	1	20% (CI 0–55)	3	14% (CI 0–29)
Cesarean delivery	5	31% (CI 8–54)	4	80% (CI 45–100)	9	43% (CI 22–64)
At diagnosis		Median (range)		Median (range)		Median (range)
Age (yr)	16	3.2 (1; 13.6) (IQR 2.6; 4.9)	5	5.1 (1; 10.5) (IQR 5; 5.6)	21	3.6 (1; 13.6) (IQR 2.6; 5.5)
Bone age (yr)	12	1.5 (0.5; 9.5) (IQR 1.2; 2.3)	4	2.2 (0.5; 4) (IQR 1.6; 2.9)	16	1.7 (0.5; 9.5) (IQR 1.2; 2.5)
Bone age delay (yr)	12	1.3 (0.5; 4.1) (IQR 1; 1.7)	4	2.8 (0.5; 6.4) (IQR 2; 3.9)	16	1.4 (0.5; 6.4) (IQR 1; 2.6)
Target height (SDS)	16	−0.2 (−1.6; 1.5) (IQR –0.7; 0.3)	5	−0.3 (−1.5; 0.6) (IQR –0.6; 0.4)	21	−0.3 (−1.6; 1.5) (IQR –0.6; 0.4)
Height (SDS)	16	−2.7 (−4.3; −1.3) (IQR –3.7; −2.3)	5	−2.2 (−2.4; −2) (IQR –2.2; −2)	21	−2.5 (−4.3; −1.3) (IQR –3.5; −2)
Height velocity (SDS)	16	−3 (−4.1; 0.3) (IQR –3.3; −1.6)	5	−3.3 (−4.2; 0) (IQR –3.4; −3.2)	21	−3.1 (−4.2; 0.3) (IQR –3.4; −1.6)
Weight (SDS)	16	−2.5 (−4; −0.4) (IQR –3; −1.9)	5	−0.7 (−1.3; 1.1) (IQR –1.2; −0.3)	21	−2.4 (−4; 1.1) (IQR –2.8; −1)
BMI (SDS)	16	−0.9 (−3.7; 2.2) (IQR –1.5; 0.2)	5	1.3 (−0.2; 4) (IQR –0.1; 1.7)	21	−0.23 (−3.7; 4) (IQR –1.1; 0.5)
GH peak (ng/mL)	16	3.2 (1.5; 23) (IQR 2; 6.7)	5	2.1 (0.5; 4.1) (IQR 0.9; 3.1)	21	3 (0.5; 23) (IQR 2; 5.5)
IGF-1 (ZS)	16	−2.9 (−5.1; −2) (IQR –4; −2.4)	5	−4.8 (−5; −4.1) (IQR –4.9; −4.4)	21	−3.1 (−5; −2) (IQR –4.4; −2.7)

CI: confidence interval 95%.

IQR: interquartile range.

GHD: growth hormone deficiency.

MPD: multiple pituitary deficiencies.

SDS: standard deviation score.

ZS: Z-score.