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. 2011 Jan 27;6(1):e16466. doi: 10.1371/journal.pone.0016466

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Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Immunofluorescence staining of monolayer (A1-3 and B1-3) and spheroid (C1-3 and D1-3) cultures from UT-SCC24A with antibodies directed against α-SMA (green) and Vimentin (red). All of the SDC (panel C and D) show high levels of the mesenchymal markers α-SMA and Vimentin compared to their monolayer counterparts. (B) E-Cadherin expression analysis by FACS. Compared to their monolayer counterparts, spheroids showed decreased E-Cadherin expression; two populations of cells derived from UT-SSC24A can be separated according to the E-Cadherin expression level, which indicates that the SDC have acquired myofibroblast characteristics by EMT.