Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Jan 27;6(1):e16561. doi: 10.1371/journal.pone.0016561

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Fierro-González et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

TRX-1 is a novel modulator of the insulin-like neuropeptide DAF-28 during dauer formation. It modulates DAF-28 signaling, upstream of DAF-2, by specifically contributing to the down-regulation of daf-28 expression during dauer formation; this modulatory process is likely subject to DAF-28-mediated feedback regulation (black dashed line). In addition, TRX-1 possibly affects dauer formation independently of both DAF-28 and DAF-2 by modulating other neuropeptides co-expressed in ASJ neurons (see Results and Discussion for details).