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. Author manuscript; available in PMC: 2011 Nov 9.
Published in final edited form as: Biochemistry. 2010 Nov 9;49(44):9613–9619. doi: 10.1021/bi1011157

Figure 3.

Figure 3

Solvent deuterium isotope effects. Circles and squares represent experimentally determined values, open circles in the presence of H2O, squares, in the presence of 98% D2O (top). Proton inventory of the solvent kinetic isotope effects. Nicotinamide was used as the substrate under saturating conditions and the amount of D2O was varied from 0 to 98%. (bottom)