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. 2011 Jan 4;108(4):1555–1560. doi: 10.1073/pnas.1017729108

Fig. 4.

Fig. 4.

TI immune responses. (A) Reduced TNP-specific IgM. WT and KO mice (n = 6 per group) were i.p. injected with 25 μg TNP-Ficoll. Serum samples were analyzed by ELISA on days 7 and 14 after immunization. Day 0, preimmunization. Data are Ig titers of individual mice. Horizontal bars indicate mean values. (B) Decreased resistance to VSV. WT and KO mice (n = 6 per group) were i.p. injected with 105 pfu VSV and viability was analyzed using Kaplan–Meier methodology. (C and D) Reduced anti-VSV neutralizing Abs. Serum samples from the mice in B were analyzed by ELISA on day 0 (preinfection) and on days 2, 4, 6, and 8 after infection to detect total anti-VSV IgM plus IgG (C) or VSV-specific IgG (D). **P < 0.005; ns, not significant.