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. 2011 Jan 4;108(4):1681–1686. doi: 10.1073/pnas.1016424108

Fig. 2.

Fig. 2.

Impaired neuronal maturation in the dentate gyrus of HSF1-deficient mice. (A) BrdU was given 2 h before mice were killed to examine the effects of HSF1 deficiency on cell proliferation. BrdU+ cells were counted from six animals per group. (B) BrdU was given once a day for 4 d before mice were killed to examine the effects of HSF1 deficiency on cell survival. BrdU+ cells were counted from six animals per group. (C) Graph shows the percentages of BrdU+ neurons, astrocytes, and other cells in the granule cell layer. (D) Images of PSA-NCAM staining in brain sections of HSF1+/+ and HSF1−/− mice. (E) Western blotting of PSA-NCAM levels in the hippocampus of HSF1+/+, HSF1+/−, and HSF1−/− mice (n = 6 for each group). (F) Images of DCX staining in brain sections of HSF1+/+ and HSF1−/− mice. (Insets) High-magnification images of DCX+ cells. (G) Effect of HSF1 deficiency on the total number of DCX+ cells (n = 6 for each group). *P < 0.05; **P < 0.01.