Fig. 4.
Time-activity curves of [18F]F-PEG6-IPQA–derived radioactivity (percent ID per gram) in different tumors (A) at baseline and (B) after pretreatment of animals with iressa. Quantification of [18F]F-PEG6-IPQA accumulation in different tumor xenografts at baseline (blue bars) and after pretreatment with iressa (red bars). (C) The rate of unidirectional accumulation (Ki) of [18F]F-PEG6-IPQA determined using Patlak graphical analysis and (D) binding potential (BP) of [18F]F-PEG6-IPQA determined by Logan model-independent graphical analysis. Bars are SEs; statistically significant differences (P < 0.05) are indicated by an asterisk.