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. 2011 Jan 10;108(4):1657–1662. doi: 10.1073/pnas.1018375108

Fig. 4.

Fig. 4.

Circadian disruption results in changes in emotionality. Emotionality was assessed by OFT and LD box (LDB) task. CD mice entered the center of the OFT faster than controls (t test, P = 0.0006; A), while not spending any additional time in the center per entry (t test, P = 0.1331; B) or demonstrating any more locomotor activity (t test, P = 0.3735; C). In the LBD, CD mice emerged from the “safe” dark compartment into the bright compartment much faster than controls (unpaired t test with Welch's correction for unequal variance, P = 0.0277; D), and without making any more attempts to enter the region (t test, P = 0.2608; E) or spending any more time in the lit region (t test, P = 0.1905; F).