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. 2011 Jan 10;108(4):1397–1402. doi: 10.1073/pnas.1018898108

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Fig. 1. — Breast CSCs are induced at a specific time during transformation. (A) CD44/CD24 profiles of ER-Src cells that were or were not treated with TAM for 36 h. Number of mammospheres per 1,000 cells (representative mammosphere shown) generated by sorted CSCs (CD44^high/CD24^low) and NSCCs (CD44^low/CD24^high). (B) Tumor incidence in mouse xenografts injected with the indicated number of CSCs or NSCCs isolated by sorting. (C) Percent viable CSCs and NSCCs after treatment with indicated concentrations of paclitaxel, doxorubicin, and 5-fluorouracil. (D) Proportion (percent) of CSCs at the indicated times after treatment of ER-Src cells with TAM.