Table 1.
Histologic features in CfH−/− MRL-lpr mice
| Feature | 8 Weeks |
12 Weeks |
||||
|---|---|---|---|---|---|---|
| CfH+/+ | CfH+/− | CfH−/− | CfH+/+ | CfH+/− | CfH−/− | |
| Glomerular IgG | 0.8 ± 0.2 | 0.5 ± 0.2 | 1.9 ± 0.3a | 1.8 ± 0.5 | 0.8 ± 0.3 | 2.5 ± 0.3b |
| Glomerular C3 | 0.6 ± 0.1 | 0.6 ± 0.1 | 3.5 ± 0.2a | 1.5 ± 0.4 | 0.7 ± 0.2 | 3.3 ± 0.3a |
| GN | 0.1 ± 0.1 | 0 | 0.9 ± 0.2a | 0.4 ± 0.3 | 0 | 2.6 ± 0.4a |
| GS | 0 | 0 | 0.2 ± 0.2 | 0 | 0 | 1.3 ± 0.5c |
| % GS/hyalinosis | 0 | 0 | 0.1 ± 0.1 | 0 | 0 | 13.7 ± 8.9c |
| % crescents | 0 | 0 | 0 | 0.1 ± 0.1 | 0 | 11.0 ± 6.7d |
Shown are scores of histopathologic features in different groups of MRL-lpr mice at 8 and 12 weeks of age. Data are means ± SEM. GS, glomerulosclerosis.
aP < 0.01; cP = 0.035; and dP = 0.023 versus CfH+/+ and CfH+/− MRL-lpr mice.
bP < 0.05 versus CfH+/−/MRL-lpr mice.