Table 3.

Recipient C4 gene copy number and clinical outcome - multivariate Cox regression analysis

Recipient Gene Copy Number	Number of Transplants	Graft Survival		Death-censored Graft Survival		Patient Survival
		Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P
C4
<4	513	1.00 (0.85 to 1.18)	0.99	1.06 (0.86 to 1.31)	0.59	0.94 (0.75 to 1.19)	0.62
4	1166	1.00 (reference group)		1.00 (reference group)		1.00 (reference group)
>4	290	0.95 (0.77 to 1.17)	0.62	0.92 (0.70 to 1.20)	0.54	1.01 (0.77 to 1.33)	0.95
C4A
<2	341	1.00 (0.82 to 1.21)	0.99	0.97 (0.76 to 1.25)	0.84	1.08 (0.84 to 1.40)	0.56
2	1125	1.00 (reference group)		1.00 (reference group)		1.00 (reference group)
>2	503	1.04 (0.88 to 1.23)	0.68	1.00 (0.81 to 1.23)	0.99	1.09 (0.87 to 1.37)	0.45
C4B
<2	559	1.04 (0.89 to 1.22)	0.64	1.10 (0.90 to 1.34)	0.36	0.97 (0.78 to 1.21)	0.81
2	1260	1.00 (reference group)		1.00 (reference group)		1.00 (reference group)
>2	150	0.94 (0.72 to 1.24)	0.68	0.93 (0.65 to 1.33)	0.70	1.05 (0.73 to 1.50)	0.80
C4L
<3	581	0.98 (0.82 to 1.17)	0.81	1.04 (0.83 to 1.30)	0.76	0.98 (0.77 to 1.25)	0.89
3	702	1.00 (reference group)		1.00 (reference group)		1.00 (reference group)
>3	686	0.94 (0.79 to 1.11)	0.48	1.02 (0.82 to 1.26)	0.88	0.97 (0.77 to 1.22)	0.82
C4S
0	715	1.03 (0.88 to 1.20)	0.74	1.14 (0.94 to 1.40)	0.18	0.97 (0.78 to 1.20)	0.75
1	869	1.00 (reference group)		1.00 (reference group)		1.00 (reference group)
>1	385	1.04 (0.86 to 1.26)	0.65	1.10 (0.86 to 1.40)	0.47	0.99 (0.76 to 1.28)	0.91

CI, confidence interval.