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For 6,017 charted ventilator settings from 402 children with acute hypoxemic respiratory failure, FiO2 was changed 1,869 times. When practitioners change FiO2 they frequently make changes at intervals of 0.05, both for increases and decreases of FiO2. This is in contrast to the Acute Respiratory Distress Syndrome Network protocol, which implements changes in FiO2 at intervals of 0.1. Reprinted with permission from Reference 56.
