TABLE 3.
RESULTS OF THE FAMILY-BASED ASSOCIATION ANALYSES IN THE ICGN POPULATION
| Number of Info Families | Risk Allele | P Value | |
|---|---|---|---|
| CHRNA rs8034191 | |||
| FEV1/FVC | 287 | C | 1.85 × 10−5 |
| Number of cigarettes smoked per day | 287 | C | 0.01 |
| Age started smoking cigarettes | 287 | C | 0.16 |
| Pack-years of smoking | 301 | C | 0.0003 |
| Body mass index | 286 | C | 0.18 |
| Emphysema, −950 HU* | 119 | C | 0.0082 |
| Emphysema radiologist score, % | 198 | C | 4.82 × 10−5 |
| Pi 10* | 105 | C | 0.94 |
| HHIP rs13118928 | |||
| FEV1/FVC | 301 | A | 0.0042 |
| Number of cigarettes smoked per day | 301 | A | 0.06 |
| Age started smoking cigarettes | 301 | A | 0.651 |
| Pack-years smoking | 301 | A | 0.102 |
| Body mass index | 301 | A | 0.301 |
| Emphysema, −950 HU* | 144 | A | 0.01 |
| Emphysema radiologist score, % | 219 | A | 0.004 |
| Pi 10* | 131 | A | 0.60 |
| FAM13A rs7671167 | |||
| FEV1/FVC | 224 | A | 0.010 |
| Number of cigarettes smoked per day | 224 | A | 0.354 |
| Age started smoking cigarettes | 224 | A | 0.633 |
| Pack-years smoking | 224 | A | 0.746 |
| Body mass index | 301 | A | 0.050 |
| Emphysema, −950 HU* | 123 | A | 0.172 |
| Emphysema radiologist score, % | 80 | A | 0.200 |
| Pi 10* | 224 | A | 0.759 |
Definition of abbreviation: ICGN = International COPD Genetics Network.
*
The subjects from Holland and Liverpool centers were eliminated from these analyses, because these centers used different computed tomography scanner models.
The significant P values are shown in bold.