Figure 10.

Urokinase-type plasminogen activator (uPA) diminishes efferocytosis in vivo. Apoptotic neutrophils (10×10⁶) and 2 μg single-chain plasminogen activator (scuPA) or human serum albumin (HSA) in 50 μl phosphate-buffered saline were injected intratracheally. Two hours later, bronchoalveolar lavages were obtained and phagocytic indices determined. Data from a representative experiment are shown. A second independent experiment provided similar results. * P < 0.05 compared with the group injected intratracheally with HSA.