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. 2011 Jan 26;7(1):112–132. doi: 10.7150/ijbs.7.112

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Interfragmentary Strain Theory: A tissue cannot exist in an environment where the interfragmentary strain exceeds the strain tolerance of the extracellular matrix of the tissue. Reprinted from ¹¹² Current Orthopaedic Practice -- A Review and Research Journal, Clinical Orthopaedics and Related Research, Vol. 138, Perren S, Physical and Biological Aspects of Fracture Healing with Special Reference to Internal Fixation, Pages No. 175-196, Copyright (1979) with permission from Wolters Kluwer Health.