Figure 5.
Aggregation at different concentrations. Concentration in molecules per lattice site versus the ratio of the folding temperature (Tf) over the melting temperature (Tm). The Tm/Tf ratio of the solid line is an average over the four different structures for each potential. At millimolar concentrations (3e-6 molecules per lattice site) all models show aggregation behavior at the folding temperature. At lower concentrations, the proteins designed and simulated with a water potential (P1 and P2) are significantly more soluble.