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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Curr Opin Struct Biol. 2010 Oct 14;20(6):673–683. doi: 10.1016/j.sbi.2010.08.005

Figure 1.

Figure 1

(A) Reaction catalyzed by IPNS in the formation of the penicillin nucleus. (B) Mechanism proposed by Baldwin and co-workers for the IPNS reaction [9]. (C) Aberrant reactions occurring with ACV derivatives containing either d-α-hydroxyisovalerate [18] or 3,3-[2H]2-d-aminobutyrate in place of d-valine [8].