Pathology	Model	Etiology/Mechanism	Translation to human disease	References
Glomerulonephritis	MRL/lpr NZB/W nephritis	Spontaneous, immune complex LN	Partial	1, 2, 3
	Anti-GBM nephritis	Immune, necrosis	Partial	25, 26, 27, 28
	Anti-Thy 1 nephritis	Immune, crescents, mesangiolysis	Partial	22, 23, 24
	Alport syndrome	Early crescentic, late sclerosis	Not a model of human Alport syndrome lesions	18, 19, 20, 21
Glomerulosclerosis	Aging	Spontaneous	Good	4, 5, 6
	Buffalo/MWF	Spontaneous	Good	9, 10, 11
	Nep25/DT	Genetically engineered, podocyte toxin	Partial	12, 13
	PAN/adriamycin nephropathies	Podocyte toxin	Excellent for MCD and FSGS
	Radiation nephropathy	Radiation, direct cell injury	Good	32, 33, 34
	5/6 Nx	Surgical, decreasing nephron number	Excellent for secondary FSGS	29, 30, 31
	HIVAN	HIV transgenic systemically or podocyte specific	Good	14, 15, 16, 17
Interstitial fibrosis	UUO	Surgical	Partial	35, 36, 37
	Folic acid nephropathy	Crystal and direct tubular toxin	Good	38
	CyA nephropathy	Vasoconstriction, ischemia	Good	39
Vascular	SHR	Spontaneous, hypertension	Good	7, 8
	DOCA-salt	Vasoconstriction, hypertension	Good for primary aldosteronism, partial for usual hypertension-associated CKD	40

Abbreviations: LN, lupus nephritis; GBM, glomerular basement membrane; Nep25, nephrin-hCD25; DT, diphtheria toxin; PAN, puromycin aminonucleoside; MCD, minimal change disease; FSGS, focal segmental glomerulosclerosis; Nx, nephrectomy; HIVAN, human immunodeficiency virus-associated nephropathy; UUO, unilateral ureteral obstruction; CyA, cyclosporine A; SHR, spontaneously hypertensive rat; DOCA, deoxycorticosterone acetate.